5 Essential Elements For cees dekker
5 Essential Elements For cees dekker
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Utilizing solitary-molecule optical and AFM imaging and drive-spectroscopy methods, we find to unravel the mechanistic components of the structure and dynamics of chromosomes. Our investigation pursuits consist of:
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Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I
Sadly, For some time soon after Iijima’s report, the production of cleanse nanotubes was cumbersome. In 1996, nonetheless, the team of Richard Smalley at Rice University managed to create one-walled carbon nanotubes at significant yield. Soon just after, I contacted Smalley, and we decided to be part of forces to evaluate the transport by way of a one carbon nanotube.
2010, produced a different way (‘wedging transfer’) to govern nanostructures; to start with report of DNA translocation through graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into sound-condition nanopores
Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
Since 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. A short while ago his exploration has centered on learning mobile division with microorganisms on chip, whilst his ultimate fascination is inside the direction of noticing synthetic cells.
2000, discovery that nanotubes can carry remarkable substantial current densities; settled the controversial challenge of electronic transport by way of DNA molecules by measurements of insulating actions at the single molecule degree; and demonstration of the AFM procedure for single-molecule manipulation of nanotubes
Imagine if, as opposed to using regular leading-down silicon electronics, transistors can be developed from The underside up making use of one organic and natural molecules as the switching aspects? This idea, which grew to become The premise of right now’s industry of molecular electronics, initial emerged during the 1970s.
Bulk-surface area coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
Given that 2000 he moved to one-molecule biophysics and nanobiology, ceesdekker.net with analysis from studies of DNA loop extrusion and supercoiling to DNA translocation by nanopores. Additional lately his investigation has centered on studying chromatin construction and mobile division with bacteria on chip, although he is likewise seeking to in the end Create artificial cells from The underside up.
Nanoscientist Cees Dekker is really an amiable and flamboyant gentleman who seems Considerably younger when compared to the 62 years he essentially is – fashionable Eyeglasses, psychedelic shirt, engaging smile – although not 1 to squander time. He will take his time, but not more than required.
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2004, discovery of latest physics in translocation of DNA through nanopores; 1st experimental analyze of ions conduction in nanofluidic channels; very first electrochemistry with particular person single-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; first biophysics characterization on the mechanical Attributes of double-stranded RNA; and initial solitary-molecule review of DNA translocation by a restriction-modification enzyme.